Isatis Leaf Extract Indirubin 98% for Anti-Virus

• Certification: BRC, ISO, HACCP
• Assay Method: HPLC, UV
• Application Form: Tablet, Capsule
• Application: Food, Health Care Products
• State: Powder
• Appreance: White Fine Powder
• Model NO.: 283
• Delivery Time: 5-7days
• Latin Name: Ampelopsis Grossedentata
• Bulk Density: 0.4-0.6g/Ml
• Loss on Drying: 5.0%
• Orign: China
• Shelf Life: 2 Years
• Solvent Residue: Negative
• Transport Package: 25kg/Drum
• Specification: 98% Indirubin
• Trademark: INNER
• Origin: China
• HS Code: 1302999099
• Production Capacity: 300kg/Month

Product Description

Product Description: 

Product Name: Indirubin

Appearance: Dark Red Acicular Crystal

Purity: 98%

Test Method: UV

CAS No.: 479-41-4

Molecular Formula: C16H10N2O2

Molecular Weight: 262.2628

Solubility: Soluble in ethyl acetate, acetone, chloroform, ether, insoluble in water, slightly soluble in

                ethanol.

Density: 1.417g/cm3

Boiling Point: 496.6°C at 760 mmHg

Flash Point: 207°C

Vapour Pressure: 5.34E-10mmHg at 25°C

Shelf Life: 2 years

Storage: Keep away from sunlight, sealed in dry place.

MOQ: 1kg

Indirubin is an active ingredient of anti-leukemia isolated from dried leaves of Isatis indigotica Fort. For the treatment of chronic myeloid leukemia, the total effective rate was 87.3%. In terms of reducing white blood cells effect, Indirubin is similar to Maryland, but better than Maryland in reducing liver. Its' blood and bone marrow mitigation effect is worse than Maryland, and has no cross tolenrance with Maryland.

Indirubin also has a certain effect on acute myeloid leukemia. It can be used for abnormal myelopathy and eosinophilia. Indirubin has inhibiting effect on a variety of transplanted animal tumors, and can destroy leukemia cells. With the effect of Indirubin, cells of degeneration and necrosis show swelling and soluble necrosis. Through experimental studies it is found that Indirubin can enhance the animal's monocyte-macrophage system's phagocytosis. Indirubin has no direct effect on protein synthesis. Its' inhibition of DNA synthesis is due to inhibition of DNA polymerase, affecting the polymerization of DNA. Indirubin metabolizes in liver and gallbladder after intravenous injection or intragastric administration. After 96 hours 76.03% Indirubin was eliminated by faeces. After taking this product, the mice's blood concentration gradually increased, after 12 hours it reached the peak, slowed down after a month, maintaining a long time. Indirubin is highly distributed in liver, gallbladder and gastrointestinal. Bioavailability was 46.48%.

Indication

Indirubin has anti-cancer effect. It is clinically used for the treatment of chronic myeloid leukemia.

Usage and Dosage

Adult Dosage: 50 ~ 300mg/day, generally 200mg/day, 3 to 4 times/day by taking orally until symptoms relieved or 3 months for a course of treatment.

Dosage From

Indirubin Tablet: 25mg; 50mg; 100mg.


Specification:
 

Analysis	Specification	Results
Assay(HPLC)	≥97%	97.50%
Appearance	Dark red powder	Complies
Ash	≤1.0%	0.5%
Moisture	≤8%	5.5%
Pesticides	Negative	Complies
Heavy metals	≤10ppm	Complies
Pb	≤1.0ppm	Complies
As	≤2.0ppm	Complies
Hg	≤0.2ppm	Complies
Odor	Characteristic	Complies
Particle size	100%through 80 mesh	Complies
Microbioiogical:
Total of bacteria	≤1000cfu/g		Complies
Fungi	≤100cfu/g		Complies
Salmgosella	Negative		Complies
Coli	Negative		Complies

 

Packaging & Shipping